Analysis of 10 million immune cells linked genome accessibility to gene expression — Nature
On October 7, 2026, Nature published a brief review of a study in which gene expression and genome accessibility were analyzed simultaneously. The data covered 10 million immune cells obtained from 1,108 people.
Disease-associated changes
As the publication notes, most genetic changes associated with diseases do not directly affect the genes themselves. Instead, they may alter the strength of gene expression. This effect often occurs through modification of genome accessibility.
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Link to gene expression
The simultaneous analysis made it possible to link disease-associated changes in genome accessibility with gene expression. The results are presented in the paper by M. Kanai and co-authors, “Population-scale immune multiome atlas reveals regulatory disease mechanisms,” published in Nature. The publication identified this scientific paper as the basis for its review.
