Human brain organoids transplanted into mice without cerebral cortex — Nature

Human cerebral cortex organoids grown from stem cells were transplanted into living mice without a cerebral cortex. This experimental model was examined by the authors of a Nature review devoted to research by Kaganovsky and co-authors.

Limitations of laboratory models

Brain organoids are models created from stem cells. They have transformed the study of human-specific developmental processes and disease-related features. At the same time, such models have limitations under laboratory conditions: they cannot mature beyond a certain stage, mostly do not interact with other brain structures, and do not produce a behavioral outcome.

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Transplantation possibilities

As the review authors note, after transplantation, cellular models of the human cortex form neurons that are inaccessible for study in vitro. The authors view this approach as a way to overcome some of the limitations of laboratory models. It could also enable scientists to link brain damage to behavior.